2026-03-11T12:59:03Z https://kitakyu.repo.nii.ac.jp/oai

oai:kitakyu.repo.nii.ac.jp:02000246 2026-01-31T02:11:11Z 11:10

DOSY NMR: A Valuable Tool for Determining the Enhanced Binding Constant of Cyclodextrin Nanoparticles DOSY NMR: サイクロデキストリンナノ粒子の結合定数を決定する新規な手法 Doan Thi Ngoc Anh open access Binding constant|polyme| cyclodextrin|drug delivery system This thesis explores the impact of polymerization on the binding affinity of cyclodextrin (CD)-based nanoparticles (CDNPs) with various drug molecules. By incorporating epichlorohydrin (ECH) into CDNPs, the study demonstrates a significant enhancement in binding constants. Utilizing Diffusion-Ordered Spectroscopy Nuclear Magnetic Resonance (DOSY NMR), the mechanisms underlying this enhanced binding affinity are analyzed. The research reveals a 100-fold increase in the binding constant between CDs and alpha-mangostin, and a substantial improvement in the interaction with vanillin. Additionally, a 2:1 βCD-paroxetine inclusion complex is identified, highlighting potential drug delivery benefits, especially for hydrophobic drugs. The findings suggest that ECH-induced hydrophobicity plays a key role in these interactions. The study also investigates the biocompatibility and safety of CDNPs, offering insights into reducing nephrotoxicity associated with CDs. This research advances our understanding of CD-based nanotechnology and its potential to improve therapeutic efficacy in drug delivery systems. eng doctoral thesis VoR https://kitakyu.repo.nii.ac.jp/records/2000246 甲第264号 博士(工学) 2024-09-25 27101 北九州市立大学 https://kitakyu.repo.nii.ac.jp/record/2000246/files/(KKDE1264DA)甲第264号_ゾアン ティ ゴック アイン.pdf application/pdf 2.7 MB 2024-12-21