{"created":"2024-05-29T02:07:50.012081+00:00","id":2000137,"links":{},"metadata":{"_buckets":{"deposit":"321e222a-662b-4584-a147-d905b35f5907"},"_deposit":{"created_by":14,"id":"2000137","owner":"14","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2000137"},"status":"published"},"_oai":{"id":"oai:kitakyu.repo.nii.ac.jp:02000137","sets":["11:10"]},"author_link":[],"control_number":"2000137","item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"SPG/DNA複合体を用いたヒトDectin-1を標的とする新規ドラッグデリバリーシステムの開発とその応用","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"北九州市立大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"27101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(工学)","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本論文では、SPG/DNA複合体を利用したヒトDectin-1発現細胞向けの薬剤送達システムの開発に関する研究を行っている。複合体の構造解析、ヒトDectin-1との親和性評価、核酸医薬の送達効率検証を通じて、新しい薬剤送達システムの構築を目指す。研究はヒトDectin-1発現細胞を標的としたDDS技術の開発に焦点を当て、患者特有のDectin-1バリアントプロファイルの把握により、効果的かつ副作用の少ない治療法の提供に繋がる可能性を示している。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第256号"}]},"item_10006_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"スミヤ　カズキ","nameLang":"ja-Kana"}]}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"隅谷　和樹","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-29"}],"filename":"(KKDE1256SK)甲第256号_隅谷 和樹.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://kitakyu.repo.nii.ac.jp/record/2000137/files/(KKDE1256SK)甲第256号_隅谷 和樹.pdf"},"version_id":"61f34551-0142-40c6-9574-e7a22c306473"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DDS|SPG|Dectin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The Development and Application of Novel Drug Delivery System Targeting Human Dectin-1 with SPG/DNA Complexes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Development and Application of Novel Drug Delivery System Targeting Human Dectin-1 with SPG/DNA Complexes","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"14","path":["10"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-29"},"publish_date":"2024-05-29","publish_status":"0","recid":"2000137","relation_version_is_last":true,"title":["The Development and Application of Novel Drug Delivery System Targeting Human Dectin-1 with SPG/DNA Complexes"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-05-30T01:13:15.856668+00:00"}