{"created":"2024-12-21T05:38:09.564075+00:00","id":2000246,"links":{},"metadata":{"_buckets":{"deposit":"bc355925-a6d2-45c3-b4ec-e718caaaaba8"},"_deposit":{"created_by":14,"id":"2000246","owner":"14","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2000246"},"status":"published"},"_oai":{"id":"oai:kitakyu.repo.nii.ac.jp:02000246","sets":["11:10"]},"author_link":[],"control_number":"2000246","item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"DOSY NMR: サイクロデキストリンナノ粒子の結合定数を決定する新規な手法","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-09-25"}]},"item_10006_degree_grantor_9":{"attribute_name":"item_10006_degree_grantor_9","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"北九州市立大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"27101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(工学)","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This thesis explores the impact of polymerization on the binding affinity of cyclodextrin (CD)-based nanoparticles (CDNPs) with various drug molecules. By incorporating epichlorohydrin (ECH) into CDNPs, the study demonstrates a significant enhancement in binding constants. Utilizing Diffusion-Ordered Spectroscopy Nuclear Magnetic Resonance (DOSY NMR), the mechanisms underlying this enhanced binding affinity are analyzed. The research reveals a 100-fold increase in the binding constant between CDs and alpha-mangostin, and a substantial improvement in the interaction with vanillin. Additionally, a 2:1 βCD-paroxetine inclusion complex is identified, highlighting potential drug delivery benefits, especially for hydrophobic drugs. The findings suggest that ECH-induced hydrophobicity plays a key role in these interactions. The study also investigates the biocompatibility and safety of CDNPs, offering insights into reducing nephrotoxicity associated with CDs. This research advances our understanding of CD-based nanotechnology and its potential to improve therapeutic efficacy in drug delivery systems.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"dissertation_number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第264号"}]},"item_10006_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"ゾアン　ティ　ゴック　アイン","nameLang":"ja"}]}]},"item_10006_version_type_18":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Doan Thi Ngoc Anh","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-21"}],"filename":"(KKDE1264DA)甲第264号_ゾアン ティ ゴック アイン.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://kitakyu.repo.nii.ac.jp/record/2000246/files/(KKDE1264DA)甲第264号_ゾアン ティ ゴック アイン.pdf"},"version_id":"baf163ff-82df-4274-8351-787c575458fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Binding constant|polyme| cyclodextrin|drug delivery system","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"DOSY NMR: A Valuable Tool for Determining the Enhanced Binding Constant of Cyclodextrin Nanoparticles","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DOSY NMR: A Valuable Tool for Determining the Enhanced Binding Constant of Cyclodextrin Nanoparticles","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"14","path":["10"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-21"},"publish_date":"2024-12-21","publish_status":"0","recid":"2000246","relation_version_is_last":true,"title":["DOSY NMR: A Valuable Tool for Determining the Enhanced Binding Constant of Cyclodextrin Nanoparticles"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-12-21T06:55:05.558349+00:00"}