{"created":"2023-06-19T07:57:08.837494+00:00","id":773,"links":{},"metadata":{"_buckets":{"deposit":"f0b6ad0f-e43f-4156-84fc-11ff3a48d235"},"_deposit":{"created_by":14,"id":"773","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"773"},"status":"published"},"_oai":{"id":"oai:kitakyu.repo.nii.ac.jp:00000773","sets":["11:10"]},"author_link":["906"],"control_number":"773","item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"シクロデキストリン架橋ナノ粒子を用いたアルファーマンゴスチンのがん細胞へのデリバリー","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-09-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"北九州市立大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"27101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（工学）"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alpha mangostin (MGS) is a natural xanthonoid compound isolated from a tropical fruit named Mangosteen. It is highly expected as a candidate of anticancer drugs. However, its highly hydrophobic and small molecule limit on applying clinical use. To use MGS in practice, it is needed to develop a suitable drug delivery system. Cyclodextrins (CDs) are biocompatible molecules approved by FDA as the material that can be injected into the human body and have already been used for a long time. The main advantage of CD comes from its hydrophilic exterior and hydrophobic interior of cavity. Thus, CD can encapsulate hydrophobic compounds like MGS to from complex, then that complex can stay in aqueous solution. The aim of thesis is to establish CD-based nanoparticles (CDNPs) for purpose of delivering MGS effectively in cancer treatment. CDNPs were prepared by use of polyaddition reaction with epichlorohydrin. Particle properties of CDNPs were controlled by changing weight ratio of the composition in reaction. Our CDNPs have a great loading ratio of MGS in comparison with native CDs. Additionally, CDNPs containing MGS has anticancer effect on both in vitro and in vivo experiment.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第145号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ドアン　ティ, ホン　ヴァン","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"906","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"(KKDE1145DV)甲第145号_ﾄﾞｱﾝ ﾃｨ ﾎﾝ ｳﾞｧﾝ.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"(KKDE1145DV)甲第145号_ﾄﾞｱﾝ ﾃｨ ﾎﾝ ｳﾞｧﾝ","objectType":"fulltext","url":"https://kitakyu.repo.nii.ac.jp/record/773/files/(KKDE1145DV)甲第145号_ﾄﾞｱﾝ ﾃｨ ﾎﾝ ｳﾞｧﾝ.pdf"},"version_id":"b358223b-873e-40a1-830f-73584b34a863"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cyclodextrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alpha mangostin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperbranched polymers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Delivery System","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer treatment","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Establishment of Cyclodextrin-based Hyperbranched Nanoparticles for Delivering Alpha Mangostin in Cancer Treatment","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment of Cyclodextrin-based Hyperbranched Nanoparticles for Delivering Alpha Mangostin in Cancer Treatment","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"14","path":["10"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-24"},"publish_date":"2020-12-24","publish_status":"0","recid":"773","relation_version_is_last":true,"title":["Establishment of Cyclodextrin-based Hyperbranched Nanoparticles for Delivering Alpha Mangostin in Cancer Treatment"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-04-03T03:16:54.367228+00:00"}