{"created":"2023-06-19T07:57:08.904396+00:00","id":774,"links":{},"metadata":{"_buckets":{"deposit":"34fbdf3a-a530-40c1-aa7c-8b597fa0ae04"},"_deposit":{"created_by":14,"id":"774","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"774"},"status":"published"},"_oai":{"id":"oai:kitakyu.repo.nii.ac.jp:00000774","sets":["11:10"]},"author_link":["907"],"control_number":"774","item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"α-マンゴスチンの生物学的機能－がん浸潤抑制、細胞の機械特性低下、白血球の活性化―に関する研究","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-09-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"北九州市立大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"27101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（工学）"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this research, it was made clear that α-Mangostin presented its diversified biological functions, it was not only found with anti-cancer, but also has other effects with different cell types. The anti-metastasis of α-Mangostin has been found in several researches on cancer cells, but in this study, I found that α-Mangostin also had positive effect on normal cells which were surrounded cancer cells. This finding is important to optimize the conditions of this compound as a chemotherapeutic and chemopreventive agent for cancer treatment. In addition, α-Mangostin changed the mechanical properties which has been proposed to participate in regulation of cell state and fate. The mechanical properies is also play important role in leukocytes, α-Mangostin reduced the cell stiffness followed by induced the cell adhesion and activated leukocytes. These results contribute to complete the whole picture of the biological function of α-Mangostin, and these functions of α-Mangostin are useful for studies on the potential pharmacological principles as well as the preclinical applications of the α-Mangostin.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第146号"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ファン　ティ, キィウ　チャン","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"907","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"(KKDE1146PT)甲第146号_ﾌｧﾝ ﾃｨ ｷｨｳ ﾁｬﾝ.pdf","filesize":[{"value":"15.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"(KKDE1146PT)甲第146号_ﾌｧﾝ ﾃｨ ｷｨｳ ﾁｬﾝ","objectType":"fulltext","url":"https://kitakyu.repo.nii.ac.jp/record/774/files/(KKDE1146PT)甲第146号_ﾌｧﾝ ﾃｨ ｷｨｳ ﾁｬﾝ.pdf"},"version_id":"3445e7f0-902b-4932-8352-7fda4f1348e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-Mangostin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Co-culture","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell mechanics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytotoxicity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Atomic force microscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Actin cytoskeleton","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell adhesion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Leukocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Studies on the multi-biological functions of α-mangostin including inhibition of cancer metastasis, reduction of cell stiffness and activation of leukocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Studies on the multi-biological functions of α-mangostin including inhibition of cancer metastasis, reduction of cell stiffness and activation of leukocytes","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"14","path":["10"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-24"},"publish_date":"2020-12-24","publish_status":"0","recid":"774","relation_version_is_last":true,"title":["Studies on the multi-biological functions of α-mangostin including inhibition of cancer metastasis, reduction of cell stiffness and activation of leukocytes"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-04-03T03:14:25.150676+00:00"}