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Studies on the multi-biological functions of α-mangostin including inhibition of cancer metastasis, reduction of cell stiffness and activation of leukocytes
https://kitakyu.repo.nii.ac.jp/records/774
https://kitakyu.repo.nii.ac.jp/records/7748d212d22-1ed8-4c6c-896a-d09f8daa5ab0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
(KKDE1146PT)甲第146号_ﾌｧﾝ ﾃｨ ｷｨｳ ﾁｬﾝ (15.8 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-24 | |||||
| タイトル | ||||||
| タイトル | Studies on the multi-biological functions of α-mangostin including inhibition of cancer metastasis, reduction of cell stiffness and activation of leukocytes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | α-Mangostin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Co-culture | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cancer invasion | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cell mechanics | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cytotoxicity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Atomic force microscopy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Actin cytoskeleton | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cell adhesion | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Leukocyte | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | α-マンゴスチンの生物学的機能－がん浸潤抑制、細胞の機械特性低下、白血球の活性化―に関する研究 | |||||
| 言語 | ja | |||||
| 著者 |
ファン ティ, キィウ チャン
× ファン ティ, キィウ チャン |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this research, it was made clear that α-Mangostin presented its diversified biological functions, it was not only found with anti-cancer, but also has other effects with different cell types. The anti-metastasis of α-Mangostin has been found in several researches on cancer cells, but in this study, I found that α-Mangostin also had positive effect on normal cells which were surrounded cancer cells. This finding is important to optimize the conditions of this compound as a chemotherapeutic and chemopreventive agent for cancer treatment. In addition, α-Mangostin changed the mechanical properties which has been proposed to participate in regulation of cell state and fate. The mechanical properies is also play important role in leukocytes, α-Mangostin reduced the cell stiffness followed by induced the cell adhesion and activated leukocytes. These results contribute to complete the whole picture of the biological function of α-Mangostin, and these functions of α-Mangostin are useful for studies on the potential pharmacological principles as well as the preclinical applications of the α-Mangostin. | |||||
| 学位名 | ||||||
| 学位名 | 博士（工学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 27101 | |||||
| 学位授与機関名 | 北九州市立大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-09-26 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第146号 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
